Secondary school biology teachers constantly face the challenge of finding ways to connect students with topics that are engaging and relevant to them. In-vitro fertilization and other assisted reproductive technologies are increasingly common medical practices that students may hear about in their lives outside of school, whether from hearing about a celebrity couple or knowing a family member that is seeking fertility treatment. This article presents a three-day case study of a young married couple facing infertility and explores the topic of human reproduction through case study and scientific argumentation. This case study is appropriate for Grades 9-12 and aligns with the "Next Generation Science Standards," which supports disciplinary core ideas for how specialized cells within organisms help them perform essential life functions (reproduction) and how feedback mechanisms play an essential role in regulating those functions. Additionally, it focuses on exemplary science practices such as engaging in argument from evidence.