This systematic review investigated the effectiveness of acceptance and commitment therapy for the parents of children with autism spectrum disorder. PsychInfo, CINAHL, PubMed, Science Direct, and Psychology and Behavioral Sciences Collection were searched using the terms "acceptance and commitment", "autism" and "parent". A total of eight articles met the eligibility criteria. One study was a randomized controlled trial, one was quasi-experimental, and the other six were exploratory. Study outcomes concerned ACT processes, mental health, and quality of life. These studies showed that ACT interventions can be helpful for the parents of children with autism spectrum disorder. Nevertheless, as this field of research is relatively new, future research would benefit from creating a standard procedure and larger randomized controlled trials.