This study is aimed to investigate students' perceptions towards the mDPBL approach as a multimedia-based learning approach. mDPBL approach is a combination of two different teaching approaches (i.e. DIA and PBL) with multimedia. Two departments were selected in this study (i.e. Informatics Engineering and Information System). The survey was divided into two phases, pre-survey and post-survey. 276 students participated in this study. The quasi-experiment method was used with two different ways teaching strategies (i.e. traditional and mDPBL approach). The study revealed that the majority of students have a positive impact on positive learning outcomes in the mDPBL approach. A significant increase in students' perceptions of the effectiveness of the mDPBL approach is proven by an increase in the average score of students' perceptions and perceived effectiveness of 2.67 points or 8.71%, respectively.