This paper explores the entanglement of humanism and posthumanism within the Western European University, focusing on ethical implications and the role of the university in protecting the marginalised. To illustrate its arguments, it draws on a small study conducted in an ancient Italian university which specialises in Humanities and Social Sciences. The paper focuses on two key knotty issues: relationships between university aspirations to posthumanism and the colonial legacies of humanism, and the implications of holding on to humanism as a guarantor of human rights for marginalised people. It concludes by discussing the limitations of a posthuman ethics of responsibility and proposes instead a posthuman ethics of rights for the university.