This study examined the mental fitness skills (MFS) of First Generation College Students (FGCS) and its relationship to psychological resilience and academic achievement with data from 286 students from a large regional university. Cluster analysis revealed four emergent MFS profile groups: (1) strong skills; (2) weak skills; (3) go with the flow; and (4) emotionally fragile clusters. FGCS in the strong skill profile group reported higher scores for a variety of indicators of psychological resilience than their peers in the other profile groups. We discuss the implications of our findings for theory, research and practice.