Objective: The aim of the present studies was to provide a psychometric evaluation of a version of the Treatment Self-Regulation Questionnaire (TSRQ) for assessing motivations derived from self-determination theory for responsible drinking among college students. Methods: A convenience sample of 308 college student drinkers (71.7% female) were recruited for Study 1 and a random sample of 192 college student drinkers (58.9% female) were recruited for Study 2. Participants completed the TSRQ and other self-report measures in both studies. Results: In Study 1, confirmatory factor analyses supported a revised four-factor structure of the TSRQ. In Study 2, correlation analyses generally provided support for the concurrent validity of the TSRQ subscales. Conclusion: The present studies provide some initial support for the TSRQ for assessing motivations for responsible drinking. Directions for future research and implications of a measure for assessing motivations for responsible drinking among college students are discussed.