The article emphasizes the effects of blended learning program for enhancing entrepreneurial skills among women in Maharashtra with special reference to Pune district. The present study results in the creation of the entrepreneurial skill matrix that explores the necessary skills for creative entrepreneurs. Performing the entrepreneurial skill assessment is an extremely important and foremost a step of the instructional design. A significant difference was observed in posttest and pretest scores of women students, which seemingly shows that the experimental group has increased the level of entrepreneurial skills reasonably much more in posttest compared with pretest because of blended learning interventions.