The teaching strategy based on the case study guide is based on the case study guided, with teachers as the mainstay, students as the main body, and teacher-student working together to complete the teaching tasks, which is in line with Chinese education characteristics of localized teaching strategies. This teaching strategy advocates coordinating the relationship between various elements of teaching, so that teachers, students, and teaching materials maintain a coordinated state. We herein prospect through a case of a middle school in Jiangsu, China to explain the basic content of the teaching strategy, and analyze the practical exploration of the teaching strategy based on the protocol-guided study.