The focus of this study was to find out the effectiveness of the jigsaw model on improving pre-service teachers' performance in selected functional group organic compounds. The study employed the quasi-experimental non-randomized pre-test/post-test intact class design. The sample was 144 pre-service teachers comprising 72 in the experimental class and 72 in the control class. The jigsaw model was implemented in the experimental class while the conventional teaching method was implemented in the control class. The "Organic Chemistry Concept Achievement Test" was used as the research instrument to collect the data. The instrument was pilot tested, and the reliability index was found to be 0.724. The findings of the study revealed that the jigsaw model was effective in yielding significantly better performance in the selected functional group organic compounds among the pre-service teachers in the experimental group than their counterparts in the control group who were taught through the conventional method. It was found that the jigsaw model laid a good foundation for the pre-service teachers to develop problem-solving skills and creative minds leading to their improved performance in the selected functional group organic compounds.