This study's primary purpose was to investigate the difference between stress relief tools and interventions on students' blood pressure, heart rate, perceived pain, and perceived stress in a stress relief center at a university in the northwest of the United States. Usage rates of each tool and intervention were also investigated. From September 2009-August 2016, data of almost 17,000 university students voluntarily participated in using the stress relief tools and interventions and were analyzed using a quantitative causal-comparative post hoc and Pearson Product correlation methods. Some stress relief tools and interventions were used more than others. Some yielded significantly lower blood pressure, heart rates, perceived pain, and stress levels than other tools and interventions. Specific stress relief tools and interventions are preferred more than others and work more effectively than others. Having a place for students to access stress relief tools and interventions is highly recommended.