A narrative literature review was conducted with the intention of providing practitioners with foundational knowledge regarding the career development trajectory of persons with disabilities (PWD). The author selected scholarship from various disciplines including rehabilitation, psychology, and special education. In the article, the author provides an overview of career development barriers and facilitators for PWD, provides a review of self-determination theory as a framework that can be used alongside other career development interventions with PWD, discusses career development interventions that have been identified as effective with PWD within vocational rehabilitation, and lastly, provides recommendations for career intervention outcomes and research.