Collaboration between colleges of liberal arts and sciences and health professional schools provide fertile ground for undergraduate programs focused on health education, advocacy, and research. Complex collaboration can sometimes challenge disciplinary boundaries and traditional processes, which may need to be updated to maximize student learning. The urgency of the pandemic stirred creativity and accelerated planning for a multidisciplinary program in global health at the University of Pikeville (UPIKE). Ultimately, the planning coalesced around a program designed to help students: (1) recognize the importance of cultural belief systems and how they influence personal and communal health; (2) illustrate the different forms of health disparities and how social systems affect health outcomes; (3) recognize the relationship between economics, politics, and health policy and identify areas of health care change; (4) understand the research process and analyze data to promote evidence-informed health practices; and (5) incorporate principles of ethics and social responsibility through civic engagement.