Moderated mediation analysis is a valuable technique for assessing whether an indirect effect is conditional on values of a moderating variable. We review the basis of moderation and mediation and their integration into a combined model of moderated mediation within a regression framework. Thereafter, an analytic and interpretive illustration of the technique is provided in the context of a substantive school climate research question. The illustration is based on a sample of 318 high schools that examines whether school-wide student engagement mediates the association between the prevalence of teasing and bullying (PTB) and academic achievement on a state-mandated reading exam; and whether this indirect effect was moderated by student perceptions of teacher support.