Background: Several studies have reported that children of parents with mental illness have 41-70% chance of developing mental health problems. This has encouraged an increase in preventive interventions directed at these children. Objectives: This systematic review aimed to describe preventive psychological interventions addressed to children of parents who are suffering a mental disorder. We identified the aims of these treatments, their approach and components. Sociodemographic characteristics of the subjects and outcomes were examined. Method: Psycinfo and Pubmed were consulted using the PICO process. We included studies in English or Spanish describing a preventive psychological intervention. Results: 16 studies were included. Most studies were focused on promoting resilience and increasing children's understanding of the parent's disorder. Psychoeducation was included in 87,5% of treatments. Family, multifamily and children group interventions were equally used as approach. Conclusions: Psychoeducation emerged as an indispensable component of the interventions. Other frequent components comprised skills training, emotional regulation training, and playful activities. Most therapies were carried out in a group setting. Specifically, a multifamily approach is regarded as the most efficient. Most of the studies yielded significant results.