The SARS-CoV-2 virus, which causes the COVID-19 disease, has swiftly infected millions of people since it was first identified in late 2019. While much remains unknown about the virus, it is increasingly clear that many survivors (including children and adolescents) struggle with ongoing symptoms for months after they receive a negative test. According to Centers for Disease Control and Prevention's (CDC) most recent guidelines (2021), students who had COVID-19 are permitted to return to school after 10 days since symptoms first appeared if they are fever-free and other symptoms are improving. In general, children appear to recover from COVID-19 more quickly than adults and have less severe symptoms overall; most youth will recover within a few weeks and not require special support upon return to school (Götzinger et al., 2020). However, some students who return to school may experience persistent symptoms or develop post-acute COVID-19 complications. These may include dyspnea, cough, loss of smell or taste, fever, diarrhea, nausea, headache, fatigue, exercise intolerance, chest pain, cardiac arrhythmias, brain fog, and memory impairment (CDC, 2021). "Post-acute sequelae of SARS-CoV-2 (PASC) infection" is the term used by the National Institutes of Health to refer to the symptoms and complications experienced after the virus is no longer detected via testing. Many PASC symptoms resemble persistent symptoms experienced by some students who have sustained concussions (e.g., headache, fatigue, brain fog, memory impairment). Because both conditions involve "invisible" issues in previously healthy individuals, and because there is limited research on this novel coronavirus, schools might effectively apply strategies recommended for students with persistent postconcussion symptoms to support students with PASC. A collaborative care model, very gradual return to school and activity, and academic and environmental accommodations, many of which overlap with those educators use to support students with concussions, may help support students who have persistent symptoms.