There has been a wave of interest in UK academic libraries in developing services to support student well-being. This paper identifies three fundamental and interrelated issues that need to be addressed to make such initiatives effective and sustainable. Firstly, well-being has to be defined and the impacts of interventions must be measured in appropriate ways. Secondly, there is a need to identify the true nature of the underlying social problem around well-being. Thirdly, relevant approaches to the issue need to be located within the professional knowledge base of librarianship.