This is a case study of a high school science teacher in an Indigenous public school in Nepal. In this paper, we share the success of the science teacher in antiracist and critical pedagogy in his science class. We focus specifically on how the science teacher was successful in drawing students to interact with historical and cultural discrimination through science. Our data analysis identified two themes showing successful antiracist and critical science teaching that is inclusive of diverse cultural experiences. The study points to potential for antiracist and critically oriented science education for social change in the context of the Global South.