Active learning has been shown to improve student learning and engagement in many 4-year institutions; however, large-scale studies on the efficacy of active learning in community colleges are lacking. In this study, we investigate the effects of active learning in a first semester majors' general biology course at a large, suburban community college by designing and implementing a flipped active-learning model in the course. Our study included 33 sections of general biology class, 16 instructors, and ~800 students. Students in active-learning sections performed significantly higher on common exam questions than their peers in traditional sections with primarily didactic pedagogy. Although students from the active-learning sections had similar pass rates and grade distributions, they passed subsequent biology courses with significantly higher grades. The 3-year graduation rate for students from active-learning sections was also significantly higher. These findings suggest that a flipped active-learning pedagogy is more effective than traditional didactic methods for teaching general biology concepts and that the improvement in student learning may lead to higher graduation rates.