An educational escape activity was developed, embedding elements of both augmented and immersive virtual reality technologies, in an active learning environment. The mental visualization of abstract concepts can be difficult for students, inhibiting their ability to reason cogently regarding important topics of stereochemistry. Consequently, an educational escape room coupled with immersive technologies can be utilized to foster teamwork and critical thinking while encouraging student interaction with three-dimensional virtual molecular phenomena. Nine participants were recruited from the University of East Anglia to complete the activity. From this first experience, student feedback and subsequent thematic analysis show not only the significant positive impacts on student engagement and learning but also the potential of this paradigm to be adopted as an educational tool.