A comprehensive CAD/CAM dentistry curriculum that includes broad aspects of single tooth restoration has been implemented at the University of Illinois College of Dentistry (COD) since 2010. The purpose of the program is to promote an educational environment that utilizes current technology to enhance the quality and efficiency of single-tooth dental treatment offered to patients, while also preparing graduating students to apply recent and future clinical advances. This article describes the history, organization, rationale, and objectives of the tooth-supported restorative aspects of our comprehensive pre-clinical and clinical CAD/CAM curriculum and presents the educational and clinical outcomes of this program.