Although the theory of the socio-cultural approach to creativity is gaining steam, empirical studies with advanced statistical tools are lagging behind. To address the gap of empirical studies integrating individual, social environmental, and cultural factors, we examined how motivational factors and environmental responsiveness were jointly related to college students' creative achievement in different nations. Participants were university students from eight culturally and geographically diverse regions: Argentina, Austria, Chile, China, Kosovo, Russia, Saudi Arabia, and Turkey. Overall, the results painted a generally positive picture of the relationship between environmental responsiveness, motivational factors, and creative achievement. By employing structural equation modeling (SEM) and multiple-group SEM (MGSEM) methods, results partially supported the mediation role of motivational factors between environmental responsiveness and creative achievement. In addition, we observed more consistent relationships between parental responsiveness and motivational factors or creative achievement, than lecturer. This held in common across all seven countries which fulfilled the requirements for the SEM process, indicating that parents play a potential vital role in supporting students' motivational aspects and creative achievements, whereas lecturers supporting role is relative to the cultural organizational circumstances. As the first large-scale empirical study with a socio-cultural approach, we invited further discussion and proposed future cross-cultural research of this kind. Research implications and practical suggestions were addressed.