ERIC Number: EJ1297336
Record Type: Journal
Publication Date: 2021-Jul
Pages: 7
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0162-3257
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Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear Cells In Autism Spectrum Disorder (ASD)
Ceylan, Mehmet Fatih; Tural Hesapcioglu, Selma; Yavas, Cansu Pinar; Senat, Almila; Erel, Ozcan
Journal of Autism and Developmental Disorders, v51 n7 p2511-2517 Jul 2021
Genetic, neurobiological, neurochemical, environmental factors and their interactions contribute to autism phenotypes. Blood from 48 (age range: 4-17) autism spectrum disorder diagnosed patients (ASD) and 38 age- and gender-matched healthy control subjects was analyzed for numbers of neutrophils, lymphocytes, monocytes, albumin, serum Ischemia-Modified Albumin (IMA) levels and myeloperoxidase activity. The serum IMA levels, myeloperoxidase activity and peripheral blood mononuclear cells count were significantly higher in ASD cases than in the control subjects. There were no significant differences in albumin levels between the patient and control groups. These results suggest that the immune system, oxidative stress and myeloperoxidase activity may be activated in ASD. There is a clinical benefit from the early detection of ASD using myeloperoxidase activity, IMA levels and monocyte counts.
Descriptors: Autism, Pervasive Developmental Disorders, Cytology, Metabolism, Genetics, Patients, Identification
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
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Language: English
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