The present study aims to investigate the self-efficacy and goal orientation of college-level English Language Learners (ELLs). It further explored the relationship between self-efficacy and goal orientation. The data were collected from 198 ELLs by using an English Language Learning Survey. Participants had positive self-efficacy toward their English learning. ELLs who were 25 years old and above had a higher level of self-efficacy than those who were less than 25 years old. Females had a greater mastery goal orientation tendency than males. There was a positive correlation between self-efficacy and mastery goals, whereas self-efficacy was negatively correlated with performance-avoidance goals. Teachers are encouraged to provide scaffolding and set assessment focus on ELLs improvement and mastery of content to enhance their self-efficacy and facilitate adopting mastery goals.