The study aimed to identify the impact of game-based teaching practices available in different curricula on academic achievement. The study adopted meta-analysis method via grouping similar studies about that subject, theme under the heading of certain criteria, and combining the quantitative data obtained. For this purpose, 412 studies conducted between the years of 2000-2020 were examined and 54 experimental studies on the game-based teaching practices were included in the study. The data of 54 experimental studies were analyzed via the Comprehensive Meta-Analysis Program (CMA) and MetaWin programs. The study results revealed that the game-based teaching practices applied in different curricula affect the students' academic achievement positively compared to traditional practices. The effect sizes of game-based curricula were identified to significantly differ across education levels, treatment duration, sample sizes and publication types.