This study determined the effect of Learning Management system (LMS) on students performance in educational measurement and evaluation course. A non-equivalent group quasi experimental research design was adopted for the study, using a population of all the undergraduate students in Imo State University, Nigeria. A sample of 232 students was purposively selected comprising of 109 males and 123 females. An instrument titled "Measurement and evaluation Achievement Test (MEAT)" was used for data collection. The internal consistency reliability of the items of the MEAT was estimated to be 0.88 using Kuder-Richardson formula (K-R[subscript 20]) method, while the estimated temporal stability was obtained to be 0.89 using Pearson Product-moment correlation. The Data collected were analyzed using mean and standard deviation to answer the research questions while analysis of co-variance (ANCOVA) was used to test the null hypotheses. The findings of the study revealed that students taught using LMS (Moodle) performed better than those exposed to the CAI4ME Package. It was equally revealed that female students performed better than the males in both the two approaches although the male students recorded a higher gain score. Based on the findings, the researchers recommend that, LMS Packages such as Moodle should be learnt and used by lecturers of Educational Measurement and Evaluation.