The purpose of this research was to explore the opinions of second year university students on mobile phone usage and effects in Senior High Schools in Ghana. This was necessary because while the Ministry of Communication and Ministry of Education have disclosed the intention to allow the use of mobile devices in High Schools, the Ghana Education Service insists on banning their use. The study adopted the exploratory and descriptive research methods to explore the opinions of 68 second year students of a public university in Ghana. The study found that there are indeed some educational benefits if Senior High School Students are allowed to use phones in schools. However, the device can also be a deadly destructive tool for students and can make them perform poorly in their academic work. In this regard as stake holders in charge of education in Ghana are still contemplating on whether or not to allow the use of mobile phones in high schools, all the necessary considerations must be done, before the final decision is taken.