The purpose of this study was to assess the health impact of professional quality of life and self-care on student services professionals. Results of an online survey indicate that health-related quality of life was negatively associated with compassion fatigue (secondary traumatic stress and burnout) and positively associated with mindful self-care. The latter association was insignificant after controlling for compassion fatigue. Organizations should develop policies to help mitigate stressors and foster an environment conducive to self-care.