A cancer partnership was established between the University of the District of Columbia (UDC) and the Lombardi Comprehensive Cancer Center (LCCC) Georgetown University Medical Center in 2000 to focus on Cancer Prevention and Control. The major goal of the Partnership was cancer research, education, and cancer outreach. African American populations in the District of Columbia were the focus of this Partnership. This Partnership began with a planning grant (P20) from the National Cancer Institute/National Institutes of Health (NCI/NIH) and two years later it received additional funding in the form of a U56 grant from NCI/NIH. Stemming from this Partnership has been new undergraduate courses in cancer prevention, new cancer outreach activities, collaborative projects between UDC and LCCC faculty researchers, a Cancer Academy for both graduate and undergraduate students, a Bridges to the Doctorate Program for graduate students, and the designing and implementation of a UDC/LCCC jointly taught and administered Master's Program in Cancer Biology, Prevention and Control. It is hoped that many more activities will stem from this continuing Partnership, which is twenty years old. A description of the planning activities, policies to include or avoid, and outcomes will be detailed in this article.