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ERIC Number: EJ1287231
Record Type: Journal
Publication Date: 2021-Feb
Pages: 5
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: N/A
Available Date: N/A
"T"[subscript 1] Measurement by NMR Inversion Recovery: An Upper-Division Undergraduate Experiment in Advanced NMR Techniques Demonstrating the Concept of Contrast-Enhanced MRI
Trinh, Emily H.; Wolff, Anna M.; Naumiec, Gregory R.
Journal of Chemical Education, v98 n2 p587-591 Feb 2021
Nuclear magnetic resonance (NMR) spectroscopy is the tool of choice for organic chemists to determine the molecular structure of organic molecules and, as a result, is a fundamental topic in the organic chemistry curriculum. A novel laboratory module has been developed to expand the scope of NMR spectroscopy beyond structure validation at the undergraduate level to include how organic chemistry and FT-NMR spectroscopy are directly related to contrast-assisted magnetic resonance imaging (MRI). This laboratory module allows students to synthesize commercially available MRI contrast agents and exposes students to the important concepts of longitudinal relaxation time ("T"[subscript 1]) and relaxation rate ("r"[subscript 1]), and how both properties can be enhanced by paramagnetic contrast agents. By using an NMR spectrometer for inversion recovery experiments, students will be able to bridge the concepts of NMR and MRI, while understanding how organic chemistry plays a vital role in a technology that revolutionized diagnostic and therapeutic medicine.
Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A
Author Affiliations: N/A