The aim of the study is to investigate the work-family conflict experienced by female teachers working from home due to COVID-19. The case study was used in the study. The study group of the research consists of teachers who are married and have children, working from home due to the pandemic process, working in Istanbul. 17 female teachers who met the criteria of teaching by distance education, being married and having children constituted the study group of the study. A semi-structured interview form developed by the researchers was used to collect the data. Thematic analysis technique was used in analyzing the data. According to the findings, the work-family conflict experienced by female teachers working from home during the pandemic process was grouped under three themes: time-based, strain-based and behavior-based conflict. Most of the female teachers working from home stated that they could not get administrative support during the distance education process. On the other hand, it was found that female teachers were emotionally tired during the process of working from home, their job satisfaction decreased, they were stressed, they had low motivation, and they had balancing concerns between home and work. [This article was presented at International Conference on Lifelong Education and Leadership for All (ICLEL 2020).]