Background: Children with severe and profound intellectual disabilities experience multiple chronic health conditions requiring a variety of medications. The aim of this study was to explore mothers' lived experience of giving medicines to children with severe and profound intellectual disabilities. Materials and Methods: A hermeneutic phenomenological approach was adopted with a purposeful sample of 15 mothers adopted. Face-to-face interviews and participant diaries were utilised for data collection. Results: Themes were identified with one being that of "lived body" exploring how mothers "just know" or use their instincts and also the challenges they encountered in daily life when giving medicines. Conclusions: This paper provides insight into the complexity of giving medicines to children with severe and profound intellectual disabilities and the level of support required by mothers.