The aim of the study is to reveal the relationship between science-based entrepreneurship tendencies and scientific creativity levels of gifted students. In this context, students' science-based entrepreneurship tendencies and scientific creativity levels were determined. In addition, it was investigated whether science-based entrepreneurship and scientific creativity differ by gender, age and education program variables. Finally, it was discussed if scientific creativity is a predictive variable for science-based entrepreneurship. As a method, correlational research design, which is one of the quantitative research method designs, was used. The sample of the study consisted of 165 gifted students studying in a Science and Art Center (SAC) located in the Eastern Anatolian Region of Turkey in the 2019-2020 academic years. Science Based Entrepreneurship Scale (SBES) and Scientific Creativity Scale (SCS) were used as data collection tools. In the findings of the research, it was found that gifted students have a moderate level of scientific creativity and their level of science-based entrepreneurship is above average. Also, students' science-based entrepreneurship tendencies and scientific creativities do not differ by gender, age and program variables. Lastly, it was found that there was a moderate and positive correlation between scientific creativity and science-based entrepreneurship scores of gifted students and scientific creativity was a predictor of science-based entrepreneurship. At the end, these results were discussed based on the related literature and necessary recommendations were done.