We carried out a study of an instructional model that integrates flipped classroom with active learning, in-class activities into our biology course, using a mixed methods research design. According to the survey (n = 331), a majority of students found the flipped classroom engaging and helpful for class preparation and scheduling of learning. Student performance was assessed by pre- and postpeer discussion quizzes. We found that there was a significant number of students who obtained a full score with reduced response times (by an average of 81.3%) after peer discussion at week 9 and 13 of the term. There was also a noticeable difference in the normalized average scores obtained in the final examinations for 2017 as compared to 2015 (before the flip). In summary, the integration of instructional videos with conceptual questions and hands-on, in-class activities for an undergraduate biology course intended for nonmajors resulted in improved students' perceptions of engagement, biology, and scores to a moderate extent.