This empirical study aims to identify the factors influencing the use of Moodle as a Learning Management Systems (LMS) in the academic context. To fulfil this objective, a quantitative study was carried out through a questionnaire directed to Portuguese university students, which obtained a total of 631 valid answers. The results obtained, based on structural equation modelling, show that the characteristics of Moodle LMS, proposed by Innovation Diffusion Theory and Personal Innovativeness in Information Technology influence the use of this tool positively. This research contributes to advancing the literature on this subject, and for practice the importance of elaborating student-centred LMS is highlighted. These and other implications and suggestions for future research are also presented.