Boyer's four domains of scholarship provided the basis for a comparative investigation of the scholarly output of faculty members in 14 countries and at 100 English-speaking universities on the Times Higher Education World University Rankings (2013-2014) top-400 institutions. Full-time university faculty members who held tenured, tenure-track, and non-tenure-track academic appointments across three high-consensus and three low-consensus academic fields were the population of interest. The findings revealed that faculty members in US Research I and doctoral-granting universities and their international faculty counterparts in English-speaking universities publish relatively similar levels of scholarship directed toward application and discovery and have similar levels of inactivity in their publication of teaching-oriented scholarship. Tests for academic discipline-specific differences revealed little variation except for the finding that academic chemists tend to produce more publications in the application domain. Cross-national variation was also found in the publication of application-oriented scholarship. Suggestions for further research are proposed.