This paper provides glimpses of transactions in chemistry classrooms in five African countries (Burundi, Ghana, Morocco, Nigeria, and Senegal) during the COVID-19 lockdown. Members of the secondary school community in the countries including teachers, students, and school managers were unprepared for the unprecedent demand in shift from a face-to-face to an online delivery system. From a tepid, faltering start in the early days of the lockdown in Morocco, Nigeria, and Senegal, and recognizing that the end of the lockdown may not be in sight, some minuscule progress is being made in exploring virtual delivery of the chemistry curriculum. Four major challenges to online delivery of chemistry education emerged. These are a teacher capacity deficit for delivering online education, poor internet service, an erratic power supply, and severe inadequacies in infrastructure for open and distance education. Taken together along with poor teacher motivation induced by low and irregular wages, these challenges are depressants to quality chemistry teaching during the COVID-19 period. We foresee that these challenges will persist. The harsh effect of COVID-19 on the economy of all African countries is a sign that funds will be unavailable to address these challenges in the near future. A glimmer of hope can be the reprioritization of funding resources by African governments to online delivery of education, noting that blended learning will be the new normal in the coming decades.