Because of the COVID-19 pandemic in 2020, Albright College changed its classroom courses to an online format starting at the middle of the semester. This communication describes the transformation of the remaining semester for the lecture of the general chemistry course for majors. Video, ungraded and graded quizzing activities, and discussion boards were developed in an asynchronous format, while video conferencing by Zoom provided a platform for synchronous office hours. Insights from the spring semester inform plans for the online fall semester.