As the SARS-CoV-2 pandemic spread throughout the world, universities were faced with extraordinary challenges. Shelter-in-place orders were given, in-person classes were canceled, and at the University of California Irvine, instructors had less than 2 weeks to convert spring quarter classes from a face-to-face to an online format. A team-based approach was essential to making this transition. The insights gained during the design and implementation of the final quarter of a large-enrollment online organic chemistry class are shared here, as well as student perspectives on the efficacy of key components of the course. The lessons learned during this process will be instrumental when converting other face-to-face courses into effective online formats, as online classes continue in the fall.