This study aimed to investigate the effects of contextual predictability on orthographic and phonological activation during Chinese sentence reading by Cantonese-speaking readers using the error disruption paradigm. Participants' eye fixations and pupil sizes were recorded while they silently read Chinese sentences containing homophonic, orthographic, and unrelated errors. Sentences had varying amounts of contextual information leading up to target words such that some targets were more predictable than others. Results of the fixation time analysis indicated that orthographic effects were significant in first fixation and gaze duration, while phonological effects emerged later in total reading time. However, interactions between predictability and the homophonic condition were found in gaze duration. These results suggest that, while Cantonese readers activate word meanings primarily through orthography in early processing, early phonological activation can occur when facilitated by semantics in high-constraint sentence contexts. Analysis of pupillary response measurements revealed that participants' pupil sizes became larger when they read words containing orthographic errors, suggesting that orthographic error recovery processes significantly increase cognitive load.