This study aims to assess and measure students' performances using course-key performance indicators (course-KPIs) in an academic course at a Saudi university. The approach includes three aspects of assessment (i) integrating course components and correlating course learning objectives with the program learning domain, (ii) course evaluation using rubrics, and (iii) performance mesurement using a scientific method. Moreover, it presents a novel approach for performance measurement of the course learning skills. In this study, a course has been taken to demonstrate how the KPIs are measured for evaluating students' performances. This approach relies on several specific documents that are developed for the course delivery by following the National Qualification Framework (NQF) in Saudi Arabia and the guidelines of the Accreditation Board for Engineering and Technology (ABET). The performance evaluation outcomes are useful indicators that guide the teachers to improve course learning skills. It also helps the teachers in the quality delivery of the courses and ensures continuous improvement in learning and teaching. This study concludes with an emphasis on the measuring performance using course-KPIs which can be adopted for quality improvement for any academic course in higher education irrespective of data size.