This study aimed to examine the pre-service visual arts teachers' perceptions of computer self-efficacy and attitudes towards web-based instruction studying at the Faculties of Education. Their perceptions of computer self-efficacy and attitudes towards web-based instruction were compared by the variables of gender, class and academic success based on causal comparison method. The participants of the study consisted of 250 pre-service teachers who received visual arts education at the Faculties of Education at Marmara, Necmettin Erbakan, Atatürk and Gazi Universities. Data were collected through Perceptions of Computer Self-efficacy Scale and Attitudes Towards Web-based Instruction Scale. The findings showed that the pre-service visual arts teachers' perceptions of computer self-efficacy and attitudes towards web-based instruction were high. In addition, pre-service teachers' perceptions of computer self-efficacy and attitudes towards web-based instruction differed by gender and year of study. There were significant positive correlations between pre-service visual arts teachers' perceptions of computer self-efficacy and attitudes towards web-based instruction.