ERIC Number: EJ1269182
Record Type: Journal
Publication Date: 2020-Oct
Pages: 6
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0162-3257
EISSN: N/A
Available Date: N/A
Brief Report: Genetic Links between Autism and Suicidal Behavior--A Preliminary Investigation
DiBlasi, Emily; Kirby, Anne V.; Gaj, Eoin; Docherty, Anna R.; Keeshin, Brooks R.; Bakian, Amanda V.; Coon, Hilary
Journal of Autism and Developmental Disorders, v50 n10 p3525-3530 Oct 2020
Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: National Institute of Mental Health (DHHS/NIH); National Center for Advancing Translational Sciences (NCATS) (DHHS/NIH)
Authoring Institution: N/A
Grant or Contract Numbers: R01MH099134; K01MH093731; KL2TR001065
Author Affiliations: N/A