Background: Social media is a growing phenomenon, yet people with intellectual disability (ID) may not experience comparable access to this communication technology. Adolescents with ID may benefit from e-inclusion, especially as individuals with ID are at risk of having smaller social networks. Materials and Methods: The Social Network Guide was adapted to measure social media usage and used to examine the interpersonal relationships of adolescents with and without ID. Results: Adolescents with ID held smaller social networks with less developed informal relationships. However, friendship quality was comparable or superior to typically developing peers. Adolescents with ID interacted with a smaller percentage of contacts using social media. Social media use was predictive of the number of reported friendships and did not significantly predict critical comments. Conclusions: Findings suggest that adolescents with ID have comparable access to social media but use these sites to interact with a smaller number of social contacts.