The articles in the current special issue advance the literature on Tier 2 in the crucial area of discussing adaptations to existing Tier 2 interventions to enhance positive student outcomes. Adaptation is common practice in school settings. Thus, setting up recommendations, or embedding guiding principles for how to successfully adapt Tier 2 interventions is an important area of work. In this commentary, we highlight three key implications, moving beyond one size fits all, having a systematic process to guide adaptations, and establishing and supporting leadership teams in Tier 2 interventions to enhance student success. Implications for future research and school practices are provided.