The case for socio-scientific inquiry-based learning (SSIBL) based on the EU PARRISE project in schools is presented through three pillars -- citizenship education, socio-scientific issues and inquiry-based science education (IBSE) -- within the overarching context of the EU Responsible Research and Innovation (RRI) initiative. Integrating these pillars provides a model for using and building scientific knowledge to enable change by asking authentic questions ('Ask'); doing an inquiry ('Find out') and taking action ('Act').