Everyone is impacted by cultural bias due to life experiences, trauma, societal values, and exposure to prejudice and racism. Consequently, even the most well intentioned and culturally humble health care provider working in primary care pediatrics must learn to identify and reduce cultural bias. Experiencing cultural biases is often unexpected and triggers emotional, behavioral, cognitive, and physical reactions in providers. In this article, the authors describe the mnemonic, LET UP (Listen, Empathize, Tell your story, Understand, and Psychoeducate) as a method to address cultural biases in the health care setting.