This study examined associations between school violence-related stress, coping self-efficacy (CSE), job satisfaction, and quality of life (QOL) in school teachers, focusing particularly on the mediating effects of CSE and job satisfaction on teachers' QOL. The sample consisted of 528 elementary, middle, and high school teachers. The multiple mediation model analyses showed that school violence-related stress was negatively associated with QOL through CSE and job satisfaction after controlling for covariates such as type of school and years of teaching experience. Specifically, CSE and job satisfaction fully mediated the negative association between school violence-related stress and QOL. An intervention program could be useful for helping teachers to reduce their stress and improve their CSE and job satisfaction when they encounter school violence that could decrease their QOL.