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ERIC Number: EJ1242047
Record Type: Journal
Publication Date: 2020-Feb
Pages: 11
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0162-3257
EISSN: N/A
Available Date: N/A
Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference
Panjwani, Anita A.; Ji, Yuelong; Fahey, Jed W.; Palmer, Amanda; Wang, Guoying; Hong, Xiumei; Zuckerman, Barry; Wang, Xiaobin
Journal of Autism and Developmental Disorders, v50 n2 p540-550 Feb 2020
In contrast to the well-observed associations between obesity, diabetes, and autism spectrum disorder (ASD), the roles of maternal dyslipidemia and sex disparity in ASD have not been well-studied. We examined the joint associations of maternal plasma cholesterols, branched-chain amino acids (BCAAs) and child sex on child ASD risk. We analyzed data from 756 mother-infant pairs (86 ASD) from the Boston Birth Cohort. Maternal plasma cholesterols and BCAAs were measured in samples collected 24-72 h postpartum. We found that in this urban, low-income prospective birth cohort, low maternal high-density lipoprotein cholesterol (HDL-C), above-median maternal plasma BCAA concentrations, and male sex additively or synergistically increased risk of ASD. Additional studies are necessary to confirm our findings.
Springer. Available from: Springer Nature. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: customerservice@springernature.com; Web site: https://link-springer-com.bibliotheek.ehb.be/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: Health Resources and Services Administration (DHHS); National Institutes of Health (DHHS)
Authoring Institution: N/A
Grant or Contract Numbers: R40MC27443; UJ2MC31074; R21ES011666; 2R01HD041702; R21HD066471; U01AI090727; R21AI079872; R01HD086013
Author Affiliations: N/A