This study addressed the role of the reflection-informed learning and instruction (RILI) model on students' academic success by using CourseMIRROR mobile system. We hypothesized that prompting students to reflect on confusing concepts stimulates their self-monitoring activities according to which students are expected to review their understanding, search for related knowledge, and try to identify the confusing concepts. With this student-reflection information, instructors can thus address students' difficulties effectively, which can lead to enhanced academic success. We tested our hypothesis by conducting a semester-long quasi-experimental study in undergraduate industrial engineering classes (N = 153). The analyses revealed that students in the RILI condition performed significantly better than students in the control condition (Cohen's d = 0.82). In addition, reflection analysis showed that both quality and quantity of reflections were significantly associated with exam performance. Surveys indicated users highly valued the RIFI model; they rated CourseMIRROR favorably and said they would continue to use it in future classes.