This paper presents four case studies from two regional and two metropolitan Australian universities, showcasing how 3D virtual world platforms have been used to connect, engage and motivate students in both co-located and non-co-located contexts. The case studies provide practical examples of how virtual worlds and associated applications have been operationalised in real teaching and learning contexts involving a range of different disciplines. For rural educators looking for innovative ways to enrich the student learning experience, the case studies offer first hand insights into the potential and the problems of using virtual worlds for educational purposes.